Abstract The resurgence of holistic care in health care delivery poses a challenge to today's medical team. This is especially true for the nursing profession. Consequently, this poses a challenge for today's nurse to not only care for his/her patient's physical needs, but to attend to the psycho-spiritual aspects of the patient as well. This paper provides a training program for nurses to learn how to assess the spiritual needs of their patients. Based on a historical overview of nursing and the nursing process, it revisits the belief that the nursing profession's foundation is rooted in ministry to the sick as a reflection of the life and ministry of Jesus Christ. Thus, with this challenge in place, nurses are called forth to use the nursing process to assess, implement and evaluate care plans to address the spiritual needs of the patients they care for on a daily basis.