In the light of the {“Holy} Fool” genre of Christian ascetic literature, this study uses a late medieval Christian document, the Life of Brother Juniper, to examine the hagiographic presentation of someone with Asperger's syndrome-like traits, It touches on the attribution of moral and religious meaning to the persons and behaviors of those with autism spectrum disorders {(ASDs);} their inclusion in religious groups; pretence and authentic personhood; the challenges to culture, convention, and comfort, which the autistic person may offer.